Harison Ford se vraća ulozi legendarnog heroja arheologa u ovom petom nastavaku kultne franšize. Zajedno sa Fordom igraju Mads Mikkelsen (“Fantastic Beasts: The Secrets of Dumbledore”), Phoebe Waller-Bridge (“Fleabag”), Antonio Banderas (“Pain and Glory”), John Rhys-Davies (“Raiders of the Los Ark”), Shaunette Renee Wilson (“Black Panther”), Thomas Kretschmann (“Das Boot”), Toby Jones (“Jurassic World: Fallen Kingdom”), Boyd Holbrook (“Logan”), Oliver Richters (“Black Widow”) and Ethann Isidore (“Mortel”). Režirao James Mangold (“Ford v Ferrari,” “Logan”), produciraju Ketlin Kenedi, Frenk Maršal i Sajmon Emanuel, sa Stivenom Spilberg i Džordž Lukas kao izvršnim producentima.